Multimodal Imaging in Clinical Neuroscience    

The working group is primarily concerned with the investigation of individual biomarkers in psychiatry patients using PET/MR/EEG methods with a view towards its use in individually optimised therapy.

Research Focus

The research group has successfully integrated EEG system into PET/MR scanner, thereby allowing simultaneous measurement of multimodal fingerprints from PET/MR/EEG. The simultaneous PET/MRI/EEG setup is being used to understand the brain structure and function, to identify new biomarkers for neurological and psychiatric disorders, as well as to improve accuracy in early diagnosis. Another focus of the research group is utilising ultra-high field MR imaging technologies (layer fMRI, MRS, structural MRI) to aid in diagnosis and monitor the treatment responses in the Psychiatry patients at individual level. In addition, the research findings from multimodal studies are being examined to find the translational values via simultaneous fNIRS/EEG studies.

Publications

Neuner, I., Veselinović, T., Ramkiran, S. et al. 7T ultra-high-field neuroimaging for mental health: an emerging tool for precision psychiatry?. Transl Psychiatry 12, 36 (2022).

Kaulen, N., Rajkumar, R., Régio Brambilla, C. et al. (2022). mGluR₅ and GABA_A receptor-specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application. Human Brain Mapping, 43( 7), 2148– 2163.

Rajkumar R, Farrher E, Mauler J. et al. Comparison of EEG microstates with resting state fMRI and FDG-PET measures in the default mode network via simultaneously recorded trimodal (PET/MR/EEG) data. Hum Brain Mapp. 2021 Sep;42(13):4122-4133.

Rajkumar, R., Régio Brambilla, C., Veselinović, T. et al. Excitatory–inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET–MR–EEG imaging. Transl Psychiatry 11, 60 (2021).

I. Neuner et al., "Simultaneous PET-MR-EEG: Technology, Challenges and Application in Clinical Neuroscience," in IEEE Transactions on Radiation and Plasma Medical Sciences, vol. 3, no. 3, pp. 377-385, May 2019

Research Software or other Community Services

In-vivo mGluR5 and GABAA Receptor Specific Parametric PET Atlas of the Human Brain  

https://data.fz-juelich.de/dataset.xhtml?persistentId=doi:10.26165/JUELICH-DATA/HDVEEF